Fresh analysis suggests that individuals who come off popular slimming jabs like semaglutide or tirzepatide may regain lost weight much more quickly than those who stop traditional lifestyle plans.
Findings released in a prominent medical journal points out that while overweight people often shed about a fifth of their total mass while undergoing treatment, the mass comes back at an average rate of nearly a kilo each month after stopping.
"People buying these medications should be aware of the risk of rapid rebound weight gain when the treatment ends," stated expert Dr. Susan Jebb.
That rate of regain means a return to starting mass within about 18 months.
Comparing Therapies
The analysis, which looked at dozens of trials involving thousands of patients, compared the effects of these new drugs with conventional dieting.
Scientists emphasize that individuals who shed pounds through dieting usually have a slower weight regain—perhaps 0.1 kg a month—after stopping.
Explaining the Quick Rebound
Doctors believe the mechanism of the drugs accounts for the accelerated regain.
The injections mimic a natural hormone called glucagon-like peptide-1, which controls appetite.
"Sustained high doses of GLP-1 concentrations several times higher than the body's typical production might result in the system to produce less of its endogenous hormone, and could reduce sensitivity to its effects," said Dr. Adam Collins, a nutrition specialist.
"Stopping of this hormone supplement results in appetite is no longer kept in check, making binge eating a significant risk."
A Chronic Disease?
Medical guidelines advise the jabs for individuals with obesity-related health risks, accompanied by recommended lifestyle changes.
Many experts contend that, given the high risk of relapse, the treatment might need to be life-long.
This view is echoed by pharmaceutical companies, who note that the findings "underscore the persistent nature of excess weight," comparing it to managing diseases like high blood pressure.
Patient Testimonies
Users who have stopped the jabs describe a powerful return of cravings.
"It felt as if a switch flipping and you become extremely hungry," said an individual.
This challenge is compounded if individuals have not established lasting lifestyle or habit changes during therapy.
Significant Adoption
Survey data suggest that a significant number of people in the UK have tried weight-loss jabs in the last 12 months, with desire remaining high.
- Use is greater among women compared to men.
- The middle-aged demographic shows the highest usage rates.
- A large proportion obtain the medications through private prescriptions rather than the NHS.
Ultimately, experts stress that while GLP-1 drugs are effective agents for shedding pounds, they are not a magic cure and maintained weight loss likely depends on ongoing behavioural support.
